Thanks Anita for Reply .. We had also opened a SAP message and SAP has suggested note 2228845 - RZ10: New or changed value is not active after restart..Though we did not have errors as described in this note after db comparison of profile but still this is the exact scenerio we were facing . Last weekend we updated the parameter in instance profile and restarted the system and it is working fine now . This note also looks promising but bit late .
Thank you
Bhushan Chandle